Back to search

Article

Nitroxoline treatment of <i>Balamuthia mandrillaris</i> triggers genomic crisis, transcriptional collapse, and incomplete encystment via copper and iron chelation

2025-02-25

Abstract excerpt

Balamuthia mandrillaris is a free-living amoeba that can infect the central nervous system to cause granulomatous amebic encephalitis (GAE), a highly fatal disease with mortality rates up to 90%. GAE is typically treated with a six-drug regimen with limited efficacy and significant toxicity. Our lab previously identified nitroxoline, a quinolone antibiotic, as a promising therapeutic complement to the existing reg...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
65ceaf74-028c-5cf7-be6a-24d38a87396b
DOI
10.1101/2025.02.25.640156
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Nitroxoline treatment of <i>Balamuthia mandrillaris</i> triggers genomic crisis, transcriptional collapse, and incomplete encystment via copper and iron chelationDOI 10.1101/2025.02.25.640156
Clinical metagenomic identification of <i>Balamuthia mandrillaris</i> encephalitis and assembly of the draft genome: the critical need for reference strain sequencingSemantic proximity
Diagnostic Delay, Metagenomic Next-Generation Sequencing and Survival Outcomes in <em>Balamuthia mandrillaris</em> Granulomatous Amoebic Encephalitis: A Systematic Review of Global Case ReportsSemantic proximity
The transcriptome of <i>Balamuthia mandrillaris</i> trophozoites for structure-based drug designSemantic proximity
Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteriaSemantic proximity
Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteriaSemantic proximity
Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencingSemantic proximity
Modelling Amoebic Brain Infection Caused by <i>Balamuthia mandrillaris</i> Using a Human Cerebral OrganoidSemantic proximity
The pH gradient contributes to persistence in <i>Mycobacterium tuberculosis</i>Semantic proximity
Molecular, cellular and neurological consequences of infection by the neglected human pathogen NocardiaSemantic proximity
The pH gradient contributes to persistence in Mycobacterium tuberculosisSemantic proximity
Adaptive iron utilization compensates for the lack of an inducible uptake system in <i>Naegleria fowleri</i> and represents a potential target for therapeutic interventionSemantic proximity
<i>Naegleria fowleri:</i> protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoebaSemantic proximity
Select a neighboring publication to make it the new centre.