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Hormonal steroids bind the <i>Neisseria gonorrhoeae</i> multidrug resistance regulator, MtrR, to induce a multidrug binding efflux pump and stress-response sigma factor

2023-06-13

Abstract excerpt

Overexpression of the multidrug efflux pump MtrCDE, a critical factor of multidrug-resistance in Neisseria gonorrhoeae , the causative agent of gonorrheae, is repressed by the transcriptional regulator, MtrR (multiple transferable resistance repressor). Here, we report the results from a series of in vitro experiments to identify innate, human inducers of MtrR and to understand the biochemical and structural mec...

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Literature Corpus work
517d2a7f-4962-509c-adc5-43b4819e7d86
DOI
10.1101/2023.06.13.544409
Open publication

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Hormonal steroids bind the <i>Neisseria gonorrhoeae</i> multidrug resistance regulator, MtrR, to induce a multidrug binding efflux pump and stress-response sigma factorDOI 10.1101/2023.06.13.544409
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