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Transcriptomic analysis of benznidazole-resistant <i>Trypanosoma cruzi</i> clone reveals nitroreductase I-independent resistance mechanisms

2024-11-11

Abstract excerpt

The enzyme nitroreductase I (NTRI) has been implicated as the primary gene responsible for resistance to benznidazole (Bz) and nifurtimox in Trypanosoma cruzi . However, Bz-resistant T. cruzi field isolates carrying the wild-type NTR-I enzyme suggest that additional mechanisms independent of this enzyme may contribute to the resistance phenotype. To investigate these alternative mechanisms, in this paper, we pre...

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Literature Corpus work
d0d64887-7167-5785-967d-77c585c5e862
DOI
10.1101/2024.11.08.622631
Open publication

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