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Genomic and phenotypic characterization of experimentally selected resistant <i>Leishmania donovani</i> reveals a role for dynamin-1 like protein in the mechanism of resistance to a novel anti-leishmanial compound

2021-01-06

Abstract excerpt

The implementation of prospective drug resistance (DR) studies in the R&D pipelines is a common practice for many infectious diseases, but not for Neglected Tropical Diseases. Here, we explored and demonstrated the importance of this approach, using as paradigms Leishmania donovani , the etiological agent of Visceral Leishmaniasis (VL), and TCMDC-143345, a promising compound of the GSK ‘Leishbox’ to treat VL. We...

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Identifiers and source

Literature Corpus work
62800036-5d41-5e75-b93c-1a569eef48ee
DOI
10.1101/2021.01.05.425522
Open publication

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Genomic and phenotypic characterization of experimentally selected resistant <i>Leishmania donovani</i> reveals a role for dynamin-1 like protein in the mechanism of resistance to a novel anti-leishmanial compoundDOI 10.1101/2021.01.05.425522
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