Article
SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes.
Molecular oncology - 1 Jun 2018
E Hermosilla Viviana, Salgado Ginessa, Riffo Elizabeth, Escobar David, Hepp Matías I, Farkas Carlos, Galindo Mario, Morín Violeta, García-Robles María A, Castro Ariel F, Pincheira Roxana
Abstract excerpt
SALL2 is a poorly characterized transcription factor that belongs to the Spalt-like family involved in development. Mutations on SALL2 have been associated with ocular coloboma and cancer. In cancers, SALL2 is deregulated and is proposed as a tumor suppressor in ovarian cancer. SALL2 has been implicated in stemness, cell death, proliferation, and quiescence. However, mechanisms underlying roles of SALL2 related...
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