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LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity

21 Apr 2010

Abstract excerpt

Forkhead L2 (FOXL2) is expressed in the ovary and acts as a transcriptional repressor of the steroidogenic acute regulatory (StAR) gene, a marker of granulosa cell differentiation. Human FOXL2 mutations that produce truncated proteins lacking the COOH terminus result in blepharophimosis/ptosis/epicanthus inversus (BPES) syndrome type I, which is associated with premature ovarian failure (POF). In this study, we...

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PMID: 20407010
DOI: 10.1152/ajpendo.00534.2009

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LATS1 phosphorylates forkhead L2 and regulates its transcriptional activityPMID 20407010Read ↗

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