Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control

23 Aug 2012

Abstract excerpt

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) constitute an evolutionarily conserved family of protein kinases with key roles in the control of cell proliferation and differentiation. Members of the DYRK family phosphorylate many substrates, including critical regulators of the cell cycle. A recent report revealed that human DYRK2 acts as a negative regulator of G1/S transition by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down syndrome and intellectual disability research
Share to Genetics and Neurodevelopmental Disorders
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22918246
DOI: 10.4161/cc.21404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle controlPMID 22918246Read ↗

DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cellsSemantic proximity Read ↗

Multiple functions of DYRK2 in cancer and tissue developmentSemantic proximity Read ↗

Defining novel targets and functions of the protein kinase DYRK2Semantic proximity Read ↗

The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic OpportunitiesSemantic proximity Read ↗

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional rolesSemantic proximity Read ↗

New insights into the roles for DYRK family in mammalian development and congenital diseasesSemantic proximity Read ↗

DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3.Semantic proximity Read ↗

Engagement of DYRK2 in proper control for cell division.Semantic proximity Read ↗

DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesisSemantic proximity Read ↗

Emerging roles of DYRK2 in cancerSemantic proximity Read ↗

Cyclin-dependent protein kinases and cell cycle regulation in biology and diseaseSemantic proximity Read ↗

DYRK protein kinasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.