Back to search

Article

Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation: relevance in cancer prognosis

2024-06-29

Abstract excerpt

In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers. The cancer-related function of cyclin D1 has been primarily studied by focusing on the phosphorylation of the retinoblastoma (RB) gene product. Here, using an integrative approach combining bioinformatic analyses and bi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3e8c8e8d-cd6d-520f-9bc2-fbc78e7768d4
DOI
10.1101/2024.06.26.600797
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation: relevance in cancer prognosisDOI 10.1101/2024.06.26.600797
Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosisSemantic proximity
Cyclin-dependent protein kinases and cell cycle regulation in biology and diseaseSemantic proximity
Post-translational modifications on the retinoblastoma proteinSemantic proximity
Coming of Age: Targeting Cyclin K in CancersSemantic proximity
The Clinicopathological Significance of the Cyclin D1/E1–Cyclin-Dependent Kinase (CDK2/4/6)–Retinoblastoma (RB1/pRB1) Pathway in Epithelial Ovarian CancersSemantic proximity
Insights into the structural and functional activities of forgotten Kinases: PCTAIREs CDKsSemantic proximity
Cyclin-dependent kinasesSemantic proximity
Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and presentSemantic proximity
CDK12: A Potent Target and Biomarker for Human Cancer TherapySemantic proximity
Therapeutic Strategies for RB1-Deficient Cancers: Intersecting Gene Regulation and Targeted TherapySemantic proximity
Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncologySemantic proximity
A review on the role of cyclin dependent kinases in cancersSemantic proximity
Select a neighboring publication to make it the new centre.