Article
Angiotensin II receptor blockade limits kidney injury in two-kidney, one-clip Goldblatt hypertensive rats with special reference to phenotypic changes.
The Journal of laboratory and clinical medicine - 1 Feb 1999
Kobayashi S, Ishida A, Moriya H, Mori N, Fukuda T, Takamura T
Abstract excerpt
Recent evidence indicates that tubulointerstitial injury plays an important role in hypertensive kidney injury and that phenotypic changes contribute to this pathology. Moreover, angiotensin II is known to be actively involved in the pathogenesis of progressive kidney injury induced by hypertension. The present study was undertaken to see the effect of a newly developed angiotensin II type I receptor (AT1...
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