Article
Transforming growth factor-beta 1 expression and phenotypic modulation in the kidney of hypertensive rats.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 1995
Hamaguchi A, Kim S, Ohta K, Yagi K, Yukimura T, Miura K, Fukuda T, Iwao H
Abstract excerpt
We have previously reported that renal mRNA levels for transforming growth factor-beta 1, fibronectin, and collagens were increased in 32-week-old stroke-prone spontaneously hypertensive rats (SHRSP) with severe nephrosclerosis. To elucidate the mechanism of hypertension-induced nephrosclerosis,...
Topics
- Actins
- Animals
- Blotting, Northern
- Cell Division
- Cilazapril
- Gene Expression
- Genetic Markers
- Hypertension
- Immunohistochemistry
- Kidney
- Kidney Glomerulus
- Male
- Nephrosclerosis
- Nifedipine
- Phenotype
- RNA, Messenger
- Rats
- Rats, Inbred SHR