Article
Transforming growth factor-beta 1 expression and phenotypic modulation in the kidney of hypertensive rats.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 1995
Hamaguchi A, Kim S, Ohta K, Yagi K, Yukimura T, Miura K, Fukuda T, Iwao H
Abstract excerpt
We have previously reported that renal mRNA levels for transforming growth factor-beta 1, fibronectin, and collagens were increased in 32-week-old stroke-prone spontaneously hypertensive rats (SHRSP) with severe nephrosclerosis. To elucidate the mechanism of hypertension-induced nephrosclerosis, we examined gene expression and localization of transforming growth factor-beta 1 and cellular phenotype in the kidney...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
