Article
Renal proliferative and phenotypic changes in rats with two-kidney, one-clip Goldblatt hypertension.
American journal of hypertension - 1 Feb 1994
Eng E, Veniant M, Floege J, Fingerle J, Alpers C E, Menard J, Clozel J P, Johnson R J
Abstract excerpt
Angiotensin II (AII) is a vasoconstrictive peptide with hypertrophic and mitogenic effects on many cell types. Previous studies have shown that in vivo administration of AII in rats results in proliferation of, and phenotypic changes in, many renal cell populations, but in doses also causing hypertension. Thus, it was not possible to differentiate nonhemodynamic from hypertensive effects of AII. Therefore, we...
Topics
- Angiotensin II
- Animals
- Cell Division
- Cytoskeletal Proteins
- Fibrosis
- Hypertension, Renovascular
- Immunohistochemistry
- Kidney
- Leukocytes
- Macrophages
- Male