Article
Angiotensin II and IGF-I may interact to regulate tubulointerstitial cell kinetics and phenotypic changes in hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Mar 2002
Kobayashi Shuzo, Moriya Hidekazu, Nakabayashi Iwao, Nishiyama Jyunichiro, Fukuda Taneo
Abstract excerpt
Angiotensin II and insulin-like growth factor-I (IGF-I) are known to be actively involved in the pathogenesis of progressive renal injury, particularly in cell proliferation and phenotypic changes that contribute to tubulointerstitial injury. To investigate the possible mechanisms by which angiotensin II type 1 receptor antagonist (AIIA) ameliorates renal injury in a renal ablation model and to determine the...
Topics
- Actins
- Angiotensin II
- Angiotensin Receptor Antagonists
- Animals
- Cell Division
- Hypertension
- Immunohistochemistry
- Insulin-Like Growth Factor I
- Kidney
- Kidney Tubules
- Male
- Muscle, Smooth
- Phenotype
- Rats