Article
You've gotta be lucky: Coverage and the elusive gene-gene interaction.
Annals of human genetics - 1 Jan 2011
Reimherr Matthew, Nicolae Dan L
Abstract excerpt
Genome-wide association studies (GWAS) have led to a large number of single-SNP association findings, but there has been, so far, no investigation resulting in the discovery of a replicable gene-gene interaction. In this paper, we examine some of the possible explanations for the lack of findings, and argue that coverage of causal variation not only has a large effect on the loss in power, but that the effect is...
Topics
- Disease
- Epistasis, Genetic
- Genome-Wide Association Study
- Humans
- Polymorphism, Single Nucleotide