Article
The power of genome-wide association studies of complex disease genes: statistical limitations of indirect approaches using SNP markers.
Journal of human genetics - 1 Jan 2001
Ohashi J, Tokunaga K
Abstract excerpt
Genome-wide association studies using a dense map of single nucleotide polymorphism (SNP) markers seem to enable us to detect a number of complex disease genes. In such indirect association studies, whether susceptibility genes can be detected is dependent not only on the degree of linkage disequilibrium between the disease variant and the SNP marker but also on the difference in their allele frequencies. These...
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