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Article

Mutation in neurofilament transgene implicates RNA processing in the pathogenesis of neurodegenerative disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 1999

Cañete-Soler R, Silberg D G, Gershon M D, Schlaepfer W W

Abstract excerpt

A mouse neurofilament light subunit (NF-L) transgene with a 36 bp c-myc insert at the end of the coding region was found to have neuropathic effects on enteric and motor neurons of transgenic mice. The severity of phenotype was related directly to the levels of transgenic mRNA expression. High levels of transgene expression were lethal to newborn pups, causing profound alterations in the development of the...

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Identifiers

PMID: 9952405
PMCID: PMC6786029

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