Article
Mutation in neurofilament transgene implicates RNA processing in the pathogenesis of neurodegenerative disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 1999
Cañete-Soler R, Silberg D G, Gershon M D, Schlaepfer W W
Abstract excerpt
A mouse neurofilament light subunit (NF-L) transgene with a 36 bp c-myc insert at the end of the coding region was found to have neuropathic effects on enteric and motor neurons of transgenic mice. The severity of phenotype was related directly to the levels of transgenic mRNA expression. High le...
Topics
- 3' Untranslated Regions
- Animals
- CCAAT-Enhancer-Binding Proteins
- DNA Transposable Elements
- DNA-Binding Proteins
- Enteric Nervous System
- Genes, myc
- Growth
- Intestine, Small
- Mice
- Mice, Transgenic
- Motor Neurons
- Mutation
- NFI Transcription Factors
- Neurodegenerative Diseases
- Neurofilament Proteins
- Nuclear Proteins
- Phenotype