Article
Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content.
The Journal of cell biology - 4 May 1998
Elder G A, Friedrich V L, Bosco P, Kang C, Gourov A, Tu P H, Lee V M, Lazzarini R A
Abstract excerpt
Neurofilaments (NFs) are prominent components of large myelinated axons and probably the most abundant of neuronal intermediate filament proteins. Here we show that mice with a null mutation in the mid-sized NF (NF-M) subunit have dramatically decreased levels of light NF (NF-L) and increased levels of heavy NF (NF-H). The calibers of both large and small diameter axons in the central and peripheral nervous...
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