Article
Accelerated and widespread neuronal loss occurs in motor neuron degeneration (mnd) mice expressing a neurofilament-disrupting transgene.
Molecular and cellular neurosciences - 1 Dec 1995
Plummer J, Peterson A, Messer A
Abstract excerpt
To examine the effects of multiple stressors on the onset and specificity of a neurodegenerative disease, we derived mnd/mnd mice expressing a neurofilament-H/lacZ transgene. The mnd mutation causes adult-onset motor dysfunction, and produces abnormal ubiquitous accumulation of autofluorescent li...
Topics
- Animals
- Brain
- Cerebellum
- Cerebral Cortex
- Crosses, Genetic
- Female
- Genotype
- Male
- Mice
- Mice, Inbred Strains
- Mice, Neurologic Mutants
- Mice, Transgenic
- Motor Activity
- Motor Neuron Disease
- Myelin Sheath
- Nerve Degeneration
- Nerve Fibers, Myelinated
- Neurofilament Proteins