Article
Autosomal recessive neuromuscular disorder in a transgenic line of mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 1994
Kelly D, Chancellor K, Milatovich A, Francke U, Suzuki K, Popko B
Abstract excerpt
We have generated a line of transgenic mice that when homozygous for the transgene develop a severe, adult-onset neuromuscular disorder. This mutation is likely the result of the insertional inactivation of an endogenous gene by the transgene integration. The mutant mice have a gait abnormality w...
Topics
- Animals
- Genes
- Genes, Recessive
- Genes, Regulator
- Homozygote
- Mice
- Mice, Transgenic
- Mutagenesis, Insertional
- Mutation
- Myelin Basic Protein
- Neuromuscular Diseases
- Phenotype