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Article

Untranslated element in neurofilament mRNA has neuropathic effect on motor neurons of transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Sept 2002

Nie Zhenying, Wu Junhua, Zhai Jinbin, Lin Hong, Ge Weiwen, Schlaepfer William W, Cañete-Soler Rafaela

Abstract excerpt

Studies of experimental motor neuron degeneration attributable to expression of neurofilament light chain (NF-L) transgenes have raised the possibility that the neuropathic effects result from overexpression of NF-L mRNA, independent of NF-L protein effects (Cañete-Soler et al., 1999). The present study was undertaken to test for an RNA-mediated pathogenesis. Transgenic mice were derived using either an enhanced...

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Identifiers

PMID: 12196589
PMCID: PMC6758005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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