Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biphenotypic Cells and α-Synuclein Accumulation in Enteric Neurons of Leucine-Rich Repeat Kinase 2 Knockout Mice.

Digestive diseases and sciences - 1 Aug 2024

Maekawa Tatsunori, Motokawa Ryuichi, Kawashima Rei, Tamaki Shun, Hara Yusuke, Kawakami Fumitaka, Ichikawa Takafumi

Abstract excerpt

BACKGROUND: Leucine-rich repeat kinase 2 is a molecule that is responsible for familial Parkinson's disease. Our previous findings revealed that leucine-rich repeat kinase 2 is expressed in the enteric nervous system. However, which cells in the enteric nervous system express leucine-rich repeat kinase 2 and whether leucine-rich repeat kinase 2 is associated with the structure of the enteric nervous system remain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Enteric Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Mice, Knockout

Share to Neuroglia

Share to Neurons

Share to Phenotype

Source

Identifiers

PMID: 38849592
DOI: 10.1007/s10620-024-08494-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biphenotypic Cells and α-Synuclein Accumulation in Enteric Neurons of Leucine-Rich Repeat Kinase 2 Knockout Mice.PMID 38849592Read ↗

Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous systemSemantic proximity Read ↗

The metabolic kinase LKB1 shapes the enteric nervous system by mitigating the oxidative stress and p53 activitySemantic proximity Read ↗

Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson’s diseaseSemantic proximity Read ↗

Bowel dysmotility and enteric neuron degeneration in lysosomal storage disease mice is prevented by gene therapySemantic proximity Read ↗

Enteric nervous system degeneration in human and murine CLN3 disease, is ameliorated by gene therapy in miceSemantic proximity Read ↗

Phenotype and distribution pattern of nestin-GFP-expressing cells in murine myenteric plexus.Semantic proximity Read ↗

Differential Regional and Subtype-Specific Vulnerability of Enteric Neurons to Mitochondrial DysfunctionSemantic proximity Read ↗

Characterizing enteric neurons in Dopamine Transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter contentSemantic proximity Read ↗

Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse modelsSemantic proximity Read ↗

Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathologySemantic proximity Read ↗

Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-outSemantic proximity Read ↗

Molecular anatomy of the gut-brain axis revealed with transgenic technologies: implications in metabolic researchSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.