Transgenic mice in the study of ALS: the role of neurofilaments.

doi:10.1111/j.1750-3639.1998.tb00199.x

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Article

Transgenic mice in the study of ALS: the role of neurofilaments.

Brain pathology (Zurich, Switzerland) - 1 Oct 1998

Julien J P, Couillard-Després S, Meier J

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurological disorder of multiple etiologies that affects primarily motor neurons in the brain and spinal cord. Abnormal accumulations of neurofilaments (NFs) in motor neurons and a down-regulation of mRNA for the NF light subunit (NF-L) are a...

Topics

Amyotrophic Lateral Sclerosis
Animals
Humans
Mice
Mice, Transgenic
Mutation
Neurofilament Proteins
Superoxide Dismutase

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