Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Redundancy of autocrine loops in human osteosarcoma cells

9 Feb 1999

Abstract excerpt

With the aim of identifying innovative therapeutic strategies for osteosarcoma patients who are refractory to conventional chemotherapy, we analyzed the in vitro effects of the blockage of autocrine circuits. Since the insulin-like growth factor-I receptor (IGF-IR)-mediated loop is relevant to the growth of osteosarcoma, we analyzed the activity of the IGF-IR-blocking antibody alphaIR3 in both sensitive and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroblastoma Research and Treatments
Share to Sarcoma Diagnosis and Treatment
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9935160
DOI: 10.1002/(sici)1097-0215(19990209)80:4<581::aid-ijc16>3.0.co;2-o

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Redundancy of autocrine loops in human osteosarcoma cellsPMID 9935160Read ↗

IR/IGF1R signaling as potential target for treatment of high-grade osteosarcomaSemantic proximity Read ↗

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic GrowthSemantic proximity Read ↗

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic GrowthSemantic proximity Read ↗

Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.Semantic proximity Read ↗

Role of insulin-like growth factor 1 receptor signalling in cancerSemantic proximity Read ↗

Drug Repurposing of β-blocker Propranolol in Osteosarcoma: Preclinical Antitumor Efficacy Alone or in Combination with Chemotherapy.Semantic proximity Read ↗

The IGF-I/IGF-I Receptor Pathway: Implications in the Pathophysiology of Thyroid CancerSemantic proximity Read ↗

IGFBP5 domains exert distinct inhibitory effects on the tumorigenicity and metastasis of human osteosarcoma.Semantic proximity Read ↗

The IGF-I receptor in cell growth, transformation and apoptosis.Semantic proximity Read ↗

Insulin‐like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcomaSemantic proximity Read ↗

Reduced growth of human sarcoma xenografts in hosts homozygous for the lit mutation.Semantic proximity Read ↗

Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.