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Article

IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma

20 May 2013

Abstract excerpt

BACKGROUND: High-grade osteosarcoma is an aggressive tumor most often developing in the long bones of adolescents, with a second peak in the 5th decade of life. Better knowledge on cellular signaling in this tumor may identify new possibilities for targeted treatment. METHODS: We performed gene set analysis on previously published genome-wide gene expression data of osteosarcoma cell lines (n=19) and pretreatment...

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Share to Cancer, Hypoxia, and Metabolism
Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 23688189
DOI: 10.1186/1471-2407-13-245

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