Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.

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Article

Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.

Cancer research - 1 Oct 1996

Singleton J R, Randolph A E, Feldman E L

Abstract excerpt

Autocrine stimulation of the type I insulin-like growth factor receptor (IGF-IR) by IGF-II is one mechanism that allows cancer cells to maintain unregulated growth and to resist programmed cell death (PCD). SH-SY5Y and SHEP cells are cloned human neuroblastoma (NBL) lines originating from a single primary tumor. SH-SY5Y cells, which express abundant cell surface IGF-IR and produce IGF-II, exhibit serum...

Topics

Apoptosis
Gene Expression Regulation, Neoplastic
Humans
Insulin-Like Growth Factor II
Neoplasm Proteins
Neuroblastoma
Neurons
Phenotype
Receptor, IGF Type 1
Recombinant Fusion Proteins
Schwann Cells
Transfection
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8813151

Provenance

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