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Article

Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.

Cancer research - 1 Oct 1996

Singleton J R, Randolph A E, Feldman E L

Abstract excerpt

Autocrine stimulation of the type I insulin-like growth factor receptor (IGF-IR) by IGF-II is one mechanism that allows cancer cells to maintain unregulated growth and to resist programmed cell death (PCD). SH-SY5Y and SHEP cells are cloned human neuroblastoma (NBL) lines originating from a single primary tumor. SH-SY5Y cells, which express abundant cell surface IGF-IR and produce IGF-II, exhibit serum...

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PMID: 8813151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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