Article
IGFBP5 domains exert distinct inhibitory effects on the tumorigenicity and metastasis of human osteosarcoma.
Cancer letters - 9 Aug 2013
Luther Gaurav A, Lamplot Joseph, Chen Xiang, Rames Richard, Wagner Eric R, Liu Xing, Parekh Akash, Huang Enyi, Kim Stephanie H, Shen Jikun, Haydon Rex C, He Tong-Chuan, Luu Hue H
Abstract excerpt
Osteosarcoma (OS) is the most common primary malignancy of bone. We investigated the roles of insulin-like growth factor binding protein 5 (IGFBP5) domains in modulating OS tumorigenicity and metastasis. The N-terminal (to a lesser extent the C-terminal) domain inhibited cell proliferation and induced apoptosis while the C-terminal domain inhibited cell migration and invasion. The Linker domain had no independent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.