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Article

Role of insulin-like growth factor 1 receptor signalling in cancer

24 May 2005

Abstract excerpt

The insulin-like growth factor (IGF-1) signalling is highly implicated in cancer. In this signalling the IGF-1 receptor (IGF-1R) is unquestionable, the predominating single factor. IGF-1R is crucial for tumour transformation and survival of malignant cell, but is only partially involved in normal cell growth. This is in part due to the interactions with oncogenes. Recent findings suggest a close interplay with...

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PMID: 15956962
DOI: 10.1038/sj.bjc.6602627

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