Article
Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma.
The Journal of clinical investigation - 1 Sept 1994
Shapiro D N, Jones B G, Shapiro L H, Dias P, Houghton P J
Abstract excerpt
The expression of the insulin-like growth factors (IGFs) and their receptors has been linked to cellular proliferation and tumorigenicity in a number of model systems. Since rhabdomyosarcoma cells express IGF-I receptors, an autocrine or paracrine loop involving this receptor and its ligands coul...
Topics
- Blotting, Southern
- Cell Division
- Cells, Cultured
- Clone Cells
- DNA, Antisense
- DNA, Neoplasm
- Flow Cytometry
- Genetic Vectors
- Humans
- Insulin-Like Growth Factor I
- Phenotype
- Receptor, IGF Type 1
- Rhabdomyosarcoma, Alveolar
- Transfection