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Article

Reduced growth of human sarcoma xenografts in hosts homozygous for the lit mutation.

Journal of surgical oncology - 1 Oct 2002

Deitel Kevin, Dantzer Dale, Ferguson Peter, Pollak Michael, Beamer Wes, Andrulis Irene, Bell Robert

Abstract excerpt

BACKGROUND AND OBJECTIVES: Prior studies have shown that sarcoma growth can be stimulated by insulin-like growth factor-I (IGF-I). To extend this line of research, we carried out in vivo growth studies of primary human sarcoma in immunosuppressed control and IGF-I-deficient mice. METHODS: Human sarcoma specimens (one osteosarcoma and seven soft tissue sarcomas) were harvested in the operating room and implanted...

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Source

Identifiers

PMID: 12355407
DOI: 10.1002/jso.10136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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