Polymorphism of the thiopurine S-methyltransferase gene in African-Americans.

doi:10.1093/hmg/8.2.371

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Article

Polymorphism of the thiopurine S-methyltransferase gene in African-Americans.

Human molecular genetics - 1 Feb 1999

Hon Y Y, Fessing M Y, Pui C H, Relling M V, Krynetski E Y, Evans W E

Abstract excerpt

The molecular basis for the genetic polymorphism of thiopurine S -methyltransferase (TPMT) has been estab-lished for Caucasians, but it remains to be elucidated in African populations. In the current study, we determined TPMT genotypes in a population of 248 African-Americans and compared it with...

Topics

Alleles
Black People
DNA
Gene Frequency
Genes
Genotype
Heterozygote
Homozygote
Humans
Methyltransferases
Mutation
Phenotype
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
White People
Black or African American

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