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Article

Genetic analysis of thiopurine methyltransferase polymorphism in a Japanese population.

Mutation research - 14 Mar 2000

Hiratsuka M, Inoue T, Omori F, Agatsuma Y, Mizugaki M

Abstract excerpt

Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathiopurine. Several mutations in the TPMT gene have been identified which correlate with a low activity phenotype. The molecular basis for the genetic polymorphism o...

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Source

Identifiers

PMID: 10751626
DOI: 10.1016/s0027-5107(00)00004-x

Genes

TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10751626-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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