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Article

Frequency of thiopurine S-methyltransferase mutant alleles in indigenous and admixed Guatemalan patients with acute lymphoblastic leukemia.

Medical oncology (Northwood, London, England) - 1 Mar 2013

Garrido Claudia, Santizo Veronica Giron, Müllers Petra, Soriano Daphney Rigaud, Avila Giovana Bendfeldt, Dean Michael, Jimenez-Morales Silvia

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) polymorphisms affect the enzyme's activity and are predictive for the efficacy and toxicity of thiopurine treatment of acute lymphoblastic leukemia (ALL), autoimmune diseases and organ transplants. Because inter-ethnic differences in the distribution of these polymorphisms have been documented, we sequenced the TMPT gene in 95 Guatemalans, yet identified no new alleles. We...

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Identifiers

PMID: 23377985
DOI: 10.1007/s12032-013-0474-2
PMCID: PMC4545520

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TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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