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Article

Enhancer-Binding Activity of the tal-1 Oncoprotein in Association with the E47/E12 Helix-Loop-Helix Proteins

1 Jun 1991

Abstract excerpt

Almost 30% of patients with T-cell acute lymphoblastic leukemia (T-ALL) bear structural alterations of tal-1, a presumptive proto-oncogene that encodes sequences homologous to the helix-loop-helix (HLH) DNA-binding and dimerization domain. Analysis of the tal-1 gene product reveals that its HLH domain mediates protein-protein interactions with either of the ubiquitously expressed HLH proteins E47 and E12. The...

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Source

Identifiers

PMID: 2038315
DOI: 10.1128/mcb.11.6.3037-3042.1991

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancer-Binding Activity of the tal-1 Oncoprotein in Association with the E47/E12 Helix-Loop-Helix ProteinsPMID 2038315Read ↗

Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins.Semantic proximity Read ↗

Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.Semantic proximity Read ↗

Reactivation of a TAL1 progenitor cell enhancer region by non-coding somatic variants in T-lineage acute lymphoblastic leukemiaSemantic proximity Read ↗

Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells.Semantic proximity Read ↗

In-Silico analysis of TAL1, TAL2 and LYL1 gene associated with T-ALLSemantic proximity Read ↗

TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer.Semantic proximity Read ↗

mSin3A Regulates Murine Erythroleukemia Cell Differentiation through Association with the TAL1 (or SCL) Transcription FactorSemantic proximity Read ↗

ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoproteinSemantic proximity Read ↗

TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.Semantic proximity Read ↗

Sequence determinants of DNA binding by the hematopoietic helix-loop-helix transcription factor TAL1: importance of sequences flanking the E-box core.Semantic proximity Read ↗

Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.Semantic proximity Read ↗

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