Article
Loss of TAL-1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletion.
The EMBO journal - 15 May 1995
Leroy-Viard K, Vinit M A, Lecointe N, Jouault H, Hibner U, Roméo P H, Mathieu-Mahul D
Abstract excerpt
Transcriptional activation of the tal-1 gene occurs in -30% of patients with T cell Acute Lymphoblastic Leukemia and is therefore likely to be involved in human T cell leukemogenesis. However, the TAL-1 protein functional properties involved in this process have not been assessed so far. We have derived a clonal subline of the Jurkat T cell line which produced solely a mutant truncated form of TAL-1 protein....
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