Article
Loss of TAL-1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletion.
The EMBO journal - 15 May 1995
Leroy-Viard K, Vinit M A, Lecointe N, Jouault H, Hibner U, Roméo P H, Mathieu-Mahul D
Abstract excerpt
Transcriptional activation of the tal-1 gene occurs in -30% of patients with T cell Acute Lymphoblastic Leukemia and is therefore likely to be involved in human T cell leukemogenesis. However, the TAL-1 protein functional properties involved in this process have not been assessed so far. We have...
Topics
- Amino Acid Sequence
- Apoptosis
- Base Sequence
- Cell Cycle
- Cell Transformation, Neoplastic
- Clone Cells
- Culture Media
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Helix-Loop-Helix Motifs
- Leukemia, T-Cell
- Molecular Sequence Data
- Mutagenesis, Insertional
- Phenotype