Article

Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia

2023-06-29

Abstract excerpt

<title>Abstract</title> <p>TAL1 is one of the most frequently dysregulated genes in T-ALL and is overexpressed in about 50% of T-ALL cases. One of the molecular mechanisms of TAL1 overexpression is abnormal mutations in the upstream region of the TAL1 promoter that introduce binding motifs for the MYB transcription factor. MYB binding at this location creates a 5’ TAL1 super-enhancer (SE), which leads to aberrant...

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Literature Corpus work: 1913f3ab-c723-512a-9ae0-a4f54289322b
DOI: 10.21203/rs.3.rs-3069900/v1

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