The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.

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Article

The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.

Oncogene - 1 Aug 1996

Hofmann T J, Cole M D

Abstract excerpt

The TAL1 gene is transcriptionally activated by chromosomal translocation in the most common genetic lesion associated with T-cell acute lymphoblastic leukemia. TAL1 encodes a bHLH protein that exhibits sequence-specific DNA binding activity when it forms dimers with another bHLH protein such as...

Topics

Animals
Basic Helix-Loop-Helix Transcription Factors
Cell Differentiation
DNA
DNA-Binding Proteins
Fibroblasts
Helix-Loop-Helix Motifs
Mice
Mice, Inbred C3H
Muscles
Mutation
Myogenin
Proto-Oncogene Proteins
T-Cell Acute Lymphocytic Leukemia Protein 1
TATA Box
Transcription Factors
Transcriptional Activation
Transfection

Source

Open in PubMed

Identifiers

PMID: 8760303

Genes

TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8760303-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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