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Article

Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL

18 May 2016

Abstract excerpt

Trib2 is highly expressed in human T cell acute lymphoblastic leukemia (T-ALL) and is a direct transcriptional target of the oncogenic drivers Notch and TAL1. In human TAL1-driven T-ALL cell lines, Trib2 is proposed to function as an important survival factor, but there is limited information about the role of Trib2 in primary T-ALL. In this study, we investigated the role of Trib2 in the initiation and...

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PMID: 27191957
DOI: 10.1371/journal.pone.0155408

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