Article
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.
The Journal of biological chemistry - 29 Jul 2005
Wooldridge Linda, van den Berg Hugo A, Glick Meir, Gostick Emma, Laugel Bruno, Hutchinson Sarah L, Milicic Anita, Brenchley Jason M, Douek Daniel C, Price David A, Sewell Andrew K
Abstract excerpt
The off-rate (k(off)) of the T cell receptor (TCR)/peptide-major histocompatibility complex class I (pMHCI) interaction, and hence its half-life, is the principal kinetic feature that determines the biological outcome of TCR ligation. However, it is unclear whether the CD8 coreceptor, which binds pMHCI at a distinct site, influences this parameter. Although biophysical studies with soluble proteins show that TCR...
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