A genetic screen for modifiers of drosophila Src42A identifies mutations in Egfr, rolled and a novel signaling gene.

doi:10.1093/genetics/151.2.697

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Article

A genetic screen for modifiers of drosophila Src42A identifies mutations in Egfr, rolled and a novel signaling gene.

Genetics - 1 Feb 1999

Zhang Q, Zheng Q, Lu X

Abstract excerpt

Drosophila Src42A, a close relative of the vertebrate c-Src, has been implicated in the Ras-Mapk signaling cascade. An allele of Src42A, Su(Raf)1, dominantly suppresses the lethality of partial loss-of-function Raf mutations. To isolate genes involved in the same pathway where Src42A functions, w...

Topics

Animals
Drosophila
ErbB Receptors
Gene Expression Regulation
Genes, Insect
Genes, src
Mutation
Protein-Tyrosine Kinases
src Homology Domains

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