Article
Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction.
The EMBO journal - 1 Jun 1994
Lu X, Melnick M B, Hsu J C, Perrimon N
Abstract excerpt
We have identified dominant mutations that suppress the lethality associated with an R217-->L mutation in the GTP.Ras binding region (CR1) of the Drosophila raf (D-raf) serine/threonine kinase. Four intragenic and seven extragenic suppressors were recovered. Each of the four intragenic mutations...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Chromosome Mapping
- Crosses, Genetic
- Drosophila
- ErbB Receptors
- Eye
- Female
- Genes, Insect
- Male
- Molecular Sequence Data