Drosophila Src42A is a negative regulator of RTK signaling.

doi:10.1006/dbio.1999.9196

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Article

Drosophila Src42A is a negative regulator of RTK signaling.

Developmental biology - 1 Apr 1999

Lu X, Li Y

Abstract excerpt

The Src family of nonreceptor tyrosine kinases has been implicated in many signal transduction pathways. However, due to a possible functional redundancy in vertebrates, there is no genetic loss-of-function evidence that any individual Src family member has a crucial role for receptor tyrosine kinase (RTK) signaling. Here we show that an extragenic suppressor of Raf, Su(Raf)1, encodes a Drosophila Src family gene...

Topics

Alleles
Animals
Chromosome Mapping
Cloning, Molecular
Drosophila
ErbB Receptors
Gene Expression Regulation
Genes, Insect
Genes, ras
Insect Proteins
Mutation
Oogenesis
Phenotype
Proto-Oncogene Proteins c-raf
Receptor Protein-Tyrosine Kinases
Signal Transduction
Suppression, Genetic
src-Family Kinases

Source

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Identifiers

PMID: 10075855
DOI: 10.1006/dbio.1999.9196

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