Article
The Rap1 GTPase functions as a regulator of morphogenesis in vivo.
The EMBO journal - 1 Feb 1999
Asha H, de Ruiter N D, Wang M G, Hariharan I K
Abstract excerpt
The Ras-related Rap GTPases are highly conserved across diverse species but their normal biological function is not well understood. Initial studies in mammalian cells suggested a role for Rap as a Ras antagonist. More recent experiments indicate functions in calcium- and cAMP-mediated signaling and it has been proposed that protein kinase A-mediated phosphorylation activates Rap in vivo. We show that...
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