Article
The Rap1 GTPase functions as a regulator of morphogenesis in vivo.
The EMBO journal - 1 Feb 1999
Asha H, de Ruiter N D, Wang M G, Hariharan I K
Abstract excerpt
The Ras-related Rap GTPases are highly conserved across diverse species but their normal biological function is not well understood. Initial studies in mammalian cells suggested a role for Rap as a Ras antagonist. More recent experiments indicate functions in calcium- and cAMP-mediated signaling...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Division
- Cyclic AMP-Dependent Protein Kinases
- Drosophila
- Eye
- Female
- GTP-Binding Proteins
- Genes, Insect
- Morphogenesis
- Mutation
- Oogenesis
- Phenotype
- Phosphorylation
- Signal Transduction
- rap GTP-Binding Proteins
- ras Proteins