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Article

Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila.

Developmental biology - 1 Sept 2009

O'Keefe David D, Gonzalez-Niño Eduardo, Burnett Micheal, Dylla Layne, Lambeth Stacey M, Licon Elizabeth, Amesoli Cassandra, Edgar Bruce A, Curtiss Jennifer

Abstract excerpt

The small GTPase Rap1 affects cell adhesion and cell motility in numerous developmental contexts. Loss of Rap1 in the Drosophila wing epithelium disrupts adherens junction localization, causing mutant cells to disperse, and dramatically alters epithelial cell shape. While the adhesive consequences of Rap1 inactivation have been well described in this system, the effects on cell signaling, cell fate specification,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epithelium

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Source

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Identifiers

PMID: 19576205
DOI: 10.1016/j.ydbio.2009.06.032
PMCID: PMC2730837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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