Article
The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination.
Cell - 15 Nov 1991
Hariharan I K, Carthew R W, Rubin G M
Abstract excerpt
Roughened is a dominant mutation of D. melanogaster that disrupts eye development. The majority of the ommatidia in the adult eye lack a single photoreceptor cell, which is most commonly the R7 cell. The Roughened mutation disrupts the early stages of photoreceptor cell determination. Roughened is a dominant gain-of-function mutation that results from a single amino acid change (Phe157 to Leu) in the Drosophila...
Topics
- Amino Acid Sequence
- Animals
- Drosophila melanogaster
- Eye
- GTP-Binding Proteins
- Genes, Dominant
- Molecular Sequence Data
- Mutation
- Sequence Alignment
- rap GTP-Binding Proteins