Article
Genetic ablation of Rac1 in cartilage results in chondrodysplasia.
Developmental biology - 15 Jun 2007
Wang Guoyan, Woods Anita, Agoston Hanga, Ulici Veronica, Glogauer Michael, Beier Frank
Abstract excerpt
Small GTPases of the Rho family have been implicated in the regulation of many intracellular processes. However, their tissue-specific roles in mammalian growth and development in vivo remain largely unknown. Here we describe the effects of cartilage-specific inactivation of the Rac1 gene in mice. Mice carrying this mutation show increased lethality, skeletal deformities, severe kyphosis and dwarfism....
Topics
- Animals
- Bone Development
- Bone and Bones
- Cartilage
- Cell Adhesion
- Chondrocytes
- Chondrodysplasia Punctata
- Disease Models, Animal
- Genetic Predisposition to Disease
- Mice
- Mice, Knockout
- Models, Genetic
- Neuropeptides
- Phosphorylation
- Tissue Distribution
- rac GTP-Binding Proteins
- rac1 GTP-Binding Protein