Rap1, a mercenary among the Ras-like GTPases.

doi:10.1016/j.ydbio.2009.12.043

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Article

Rap1, a mercenary among the Ras-like GTPases.

Developmental biology - 1 Apr 2010

Frische E W, Zwartkruis F J T

Abstract excerpt

The small Ras-like GTPase Rap1 is an evolutionary conserved protein that originally gained interest because of its capacity to revert the morphological phenotype of Ras-transformed fibroblasts. Rap1 is regulated by a large number of stimuli that include growth factors and cytokines, but also physical force and osmotic stress. Downstream of Rap1, a plethora of effector molecules has been proposed on the basis of...

Topics

Amino Acid Sequence
Animals
Cell Adhesion
Cell Polarity
Humans
Molecular Sequence Data
Phenotype
rap1 GTP-Binding Proteins
ras Proteins

Source

Open in PubMed

Identifiers

PMID: 20060392
DOI: 10.1016/j.ydbio.2009.12.043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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