Article
Rap1, a mercenary among the Ras-like GTPases.
Developmental biology - 1 Apr 2010
Frische E W, Zwartkruis F J T
Abstract excerpt
The small Ras-like GTPase Rap1 is an evolutionary conserved protein that originally gained interest because of its capacity to revert the morphological phenotype of Ras-transformed fibroblasts. Rap1 is regulated by a large number of stimuli that include growth factors and cytokines, but also physical force and osmotic stress. Downstream of Rap1, a plethora of effector molecules has been proposed on the basis of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.