Article
Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation.
Molecular carcinogenesis - 1 Feb 2010
Michel Sara, Kloor Matthias, Singh Sandhya, Gdynia Georg, Roth Wilfried, von Knebel Doeberitz Magnus, Schirmacher Peter, Bläker Hendrik
Abstract excerpt
Approximately 15% of small intestinal adenocarcinomas show inactivation of DNA-mismatch repair (MMR) and display high-level microsatellite instability (MSI-H). MSI-H tumors progress as a result of mutations affecting coding microsatellites (coding microsatellite instability, cMSI) that may result in a functional inactivation of the encoded proteins and provide a selective growth advantage for the affected cell....
Topics
- Adenocarcinoma
- DNA Methylation
- Humans
- Immunohistochemistry
- Intestinal Neoplasms
- Intestine, Small
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- Microsatellite Repeats