Opioid receptor selectivity of heroin given intracerebroventricularly differs in six strains of inbred mice.

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Article

Opioid receptor selectivity of heroin given intracerebroventricularly differs in six strains of inbred mice.

The Journal of pharmacology and experimental therapeutics - 1 Feb 1999

Rady J J, Elmer G I, Fujimoto J M

Abstract excerpt

Heroin administered i.c.v. acts on supraspinal mu opioid receptors in ICR mice but on delta receptors in Swiss Webster mice. The purpose of this study was to determine the degree to which genotype plays a role in the opioid receptor selectivity of heroin across a range of fully inbred strains of...

Topics

Animals
Bicuculline
Dose-Response Relationship, Drug
Drug Interactions
GABA Antagonists
Genotype
Heroin
Injections, Intraventricular
Male
Methysergide
Mice
Mice, Inbred Strains
Narcotic Antagonists
Narcotics
Nociceptors
Pain Measurement
Receptors, Opioid
Serotonin Antagonists

Source

Open in PubMed

Identifiers

PMID: 9918543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9918543-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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