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Article

Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains.

Brain, behavior, and immunity - 1 Aug 2011

Liu Liang, Coller Janet K, Watkins Linda R, Somogyi Andrew A, Hutchinson Mark R

Abstract excerpt

The development of opioid dependence involves classical neuronal opioid receptor activation and is due in part to engagement of glia causing a proinflammatory response. Such opioid-induced glial activation occurs, at least in part, through a non-classical opioid mechanism involving Toll-like-receptor 4 (TLR4). Among the immune factors released following the opioid-glia-TLR4 interaction, interleukin-1β (IL-1β)...

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Source

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Identifiers

PMID: 21447380
DOI: 10.1016/j.bbi.2011.03.016
PMCID: PMC3142610

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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