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Article

Opioid operant self-administration, analgesia, stimulation and respiratory depression in mu-deficient mice.

Psychopharmacology - 1 Jan 1995

Elmer G I, Pieper J O, Goldberg S R, George F R

Abstract excerpt

It is commonly thought that mu-receptors play an important role in the reinforcing effects of opioids. In the present study, inbred strains widely divergent in CNS opiate receptor densities were used to investigate the influence of genetic variation in receptor concentration on opioid-reinforced behavior. In particular, the CXBK/ByJ mice were used as an investigative tool because of their significantly lower...

Topics

Analgesics
Animals
Benzimidazoles
Conditioning, Operant
Female
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred Strains
Motor Activity
Narcotics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Opioid, mu

Reinforcement Schedule

Respiratory Mechanics

Reward

Source

Identifiers

PMID: 7724699
DOI: 10.1007/BF02245094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7724699-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Opioid operant self-administration, analgesia, stimulation and respiratory depression in mu-deficient mice.PMID 7724699Read ↗

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