Article
Loss of expression or mutations in the p73 tumour suppressor gene are not involved in the pathogenesis of malignant melanomas.
Melanoma research - 1 Dec 1998
Kroiss M M, Bosserhoff A K, Vogt T, Buettner R, Bogenrieder T, Landthaler M, Stolz W
Abstract excerpt
Recently p73, a novel p53 homologous tumour suppressor gene, has been cloned and mapped to chromosome 1p36. Like p53, important functions of p73 in controlling the cell cycle and programmed cell death have been described. Loss of p73 has been demonstrated in neuroblastomas and its involvement in tumorigenesis has been suggested to occur in other neuroectodermal cancers. Since genetic alterations at the tumour...
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